“Unavoidable noise trade-offs in cellular processes”
Stochastic fluctuations of molecular abundances are a ubiquitous feature of biochemical processes that lead to significant cell-to-cell variability even in clonal populations under identical conditions. Despite the complexity of biochemical control networks, we can establish lower bounds for stochastic fluctuations in broad classes of systems where specific reaction motifs are embedded in unspecified networks with arbitrary interactions. I will discuss example bounds for generalized assembly processes in which molecular subunits come together to form a complex subject to arbitrary control. Such fluctuation bounds can improve our understanding of cellular processes and can guide the implementation of synthetic control circuits in cells.
Hosts: Michael Abbott and Jose Betancourt Valencia
